I connect it via USB cable (Bluetooth does not work either); Windows 7 (x64) detects that a phone is connected, but cannot connect to the phone (there is a difference in the error messages between phone attached to the cable or not)
I sincerely hope, there will be an update to MyPhoneExplorer - as HTC Sync Manager indeed CAN see the phone (I did update the HTC Sync Manager and the driver to the latest version).
Edit: My bad (Ouch!) - Phone was not turned on (read: display was off) - and hence I didn't see the confirmation dialoque on the phone requesting accept for USB-debugging (apparently some ids have changed after the sw-update). After accepting this, everything is working again